Human CDC25A (BC007401) ORF Clone in pDONR223

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Product Code: GH41490

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Product Description

Gene Name:	cell division cycle 25A
Gene ID:	993
Gene Symbol:	CDC25A
Synonyms:	CDC25A2
Species:	Homo sapiens
ACCN:	BC007401
Bacterial Selection:	Spectinomycin
Mammalian Selection:	None
Clone ID:	BC007401-ORF
Vector:	pDONR223
Collection:	Human Entry ORF 8.1
Deliverable:	Standard delivery: Glycerol stock, 2-5 μg lyophilized plasmid and sequencing report.

Background

CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene.

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