Product Description
| Reactivity: | H,M,R |
| Applications: | WB |
| Host Species: | Rabbit |
| Clonality: | Polyclonal |
| Gene Name: | Hypoxia-inducible factor 1-alpha |
Synonyms: | HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit |
Immunogen: | KLH conjugated Synthetic peptide corresponding to Human HIF1a |
Uniprot ID: | Q16665 |
Isotype: | IgG |
Purity: | Affinity purification |
Predicted MW. / Observed MW. | 83/92/97 / 110/120 kDa |
Product Usage Information
WB | Human, Mouse, Rat | 1: 300-1: 600 | HepG2, C2C12, L6 |
Background
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 40 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.
Images
| Western blot analysis of HIF1a (GB114936) at dilution of 1: 300 |
Storage
| Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
